Alan S. Tall, MD

Board Certifications: 
Internal Medicine

Overview

Academic Appointments

  • Tilden-Weger-Bieler Professor of Medicine
  • Professor of Physiology & Cellular Biophysics

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center

Gender

  • Male

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Credentials & Experience

Education & Training

  • University of Sydney, Faculty of Medicine (Australia)
  • Internship: Royal Prince Alfred Hospital
  • Residency: Boston Medical Center
  • Fellowship: Boston Medical Center

Board Certifications

  • Internal Medicine

Honors & Awards

1996 - 1998, Tenure Review Advisory Committee, Columbia; University
1993 - 1995, Committee on Appointments and Promotions, Columbia University, Chairman, 1995.

Research

The laboratory is carrying out research on the molecular mechanisms responsible for human diseases. The approach is to use molecular, genomic and cellular approaches to investigate basic aspects of the pathogenesis of atherosclerosis. A major focus is on molecular mechanisms of cellular cholesterol efflux, mediated by the interaction of extracellular apoA-I with the lipid transporter ABCA1. We are carrying out studies on the transcriptional regulation of ABCA1 gene expression, and regulation of the degradation of ABCA1 protein. This has led to the elucidation of a class of transcription factors (LXRs) that co-ordinately regulate cellular cholesterol efflux and reverse cholesterol transport.

Selected Publications

  • Wang N, Chen W, Linsel-Nitschke P, Martinez L, Agerholm-Larsen B, Silver DL, Tall AR. (2003 ) A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. J Clin Invest. 111(1):99-107
  • Tall AR. (2002 ) Exercise to reduce cardiovascular risk - how much is enough? N Engl J Med. 347(19):1522-4
  • Tall AR, Costet P, Wang N. (2002 ) Regulation and mechanisms of macrophage cholesterol efflux. J Clin Invest. 110(7):899-904
  • Jiang, XC, Qin, S, Qiao, C, Kawano, K, Lin, M, Xiao, X, Tall, AR. (2001 ) Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat. Med. 7(7):847-52
  • Luo Y, Liang CP, Tall AR. (2001 ) The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor. J Biol Chem. Jul 6;:. 276(27):24767-73
  • Welch CL, Bretschger S, Latib N, Bezouevski M, Guo Y, Pleskac N, Liang C-P, Barlow C, Dansky H, Breslow JL, Tall AR. (2001 ) Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model. PNAS 98(14):7946-51