Armin Alaedini, PhD

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Overview

Academic Appointments

  • Assistant Professor of Medicine at CUMC

My laboratory utilizes a multidisciplinary approach that includes proteomics, immunology, biochemistry, and molecular biology to study host-microbe interactions and the role of microbial and dietary antigens in immune-mediated mechanisms affecting the gastrointestinal (GI) and nervous systems. Our research is focused on the following areas:

Research Area 1 – Inflammatory response to dietary and microbial antigens in the context of GI and neuropsychiatric disease—investigating the gut-immune-brain connection.

Human intestinal mucosal surfaces are colonized by large communities of microorganisms and are in constant contact with an abundance of highly immunogenic dietary and microbial components. Proper regulation of the interaction between the host and the contents of the GI tract is of utmost importance in avoiding aberrant immune responses and requires several different mechanisms. Failure of one or more of these regulatory mechanisms can adversely affect human health, not only through GI disorders, but also in the context of systemic manifestations that may influence cognition and behavior. A primary focus of my group is investigation of the gut-immune-brain connection and the role of intestinal inflammation in the context of GI and neuropsychiatric disease. Our research is currently funded by the National Institutes of Health, the Department of Defense, and the Stanley Medical Research Institute.

Research Area 2 – Mechanisms and biomarkers of post-infection persistence of inflammation and symptoms.

In the past decade, there has been increasing interest in the etiology and biomarkers of post-infection rheumatic and neurocognitive symptoms. There is evidence that some of these symptoms are immune-mediated, possibly triggered by the inflammatory response associated with the original infection. A critical barrier to a better understanding of the associated symptoms has been the heterogeneity in etiology and the lack of biomarkers to characterize disease phenotypes and analyze treatment outcome. My laboratory is currently conducting in-depth studies to understand the connection between the bacterial strain genotype in specific infections and the persistence of inflammation and symptoms following antibiotic treatment.

PUBLICATIONS:

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48611722/?sort=date...

Gender

  • Male

Credentials & Experience

Honors & Awards

Department of Defense CDMRP Idea Award (2014)

Irving Institute for Clinical and Translational Research Pilot Award (2012)

Department of Defense CDMRP Concept Award (2010)

National Ataxia Foundation Young Investigator Award (2005)

American Neurological Association Travel Fellowship Award (2000)

Research

Investigation of the link between foreign antigens, particularly bacterial and dietary proteins, and the development of immune mediated disease processes.

Grants

INTESTINAL IMMUNE RESPONSE IN MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (Federal Gov)

Jan 15 2016 - May 31 2018

IMMUNOLOGIC MECHANISMS AND BIOMARKERS OF POST-TREATMENT LYME DISEASE SYNDROME (Private)

Feb 13 2017 - Feb 12 2018

PROTEOMIC MAPPING OF THE IMMUNE RESPONSE TO GLUTEN IN CHILDREN WITH AUTISM (Federal Gov)

Sep 30 2014 - Sep 29 2017

IMMUNOLOGICAL MECHANISMS IN CEREBRAL PALSY (Private)

Jun 11 2014 - Jun 10 2017

IMMUNOLOGIC MECHANISMS AND BIOMARKERS OF POST-TREATMENT LYME DISEASE SYNDROME (Private)

Dec 14 2015 - Dec 13 2016

MOLECULAR SPECIFICITY OF IMMUNE RESPONSE TO WHEAT IN IRRITABLE BOWEL SYNDROME (Private)

Jun 1 2015 - May 30 2016

NOVEL ANTIBODY BIOMARKERS OF POST TREATMENT LYME DISEASE SYNDROME (Private)

Oct 1 2014 - Sep 30 2015

MARKERS OF CELIAC DISEASE, GLUTEN SENSITIVITY, AND MICROBIAL TRANSLOCATION IN NE/CFS PATIENTS (Private)

Jul 1 2014 - Jun 30 2015

NORTHEAST BIODEFENSE CENTER - ADMIN CORE & SUBS (Federal Gov)

Sep 4 2003 - Feb 28 2015

IMMUNOLOGIC MECHANISMS IN POST-LYME DISEASE (Federal Gov)

Aug 17 2011 - Aug 16 2014

NOVEL ANTIBODY BIOMARKERS OF POST-TREATMENT LYME DISEASE SYNDROME (Private)

Jul 1 2013 - Jun 30 2014

SYSTEMATIC CHARACTERIZATION OF THE IMMUNE RESPONSE TO GLUTEN AND CASEIN IN AUTISM SPECTRUM DISORDERS (Federal Gov)

Aug 1 2011 - Aug 31 2013

MOLECULAR CHARACTERIZATION OF GLUTEN SENSITIVITY IN SCHIZOPHRENIA (Private)

Jul 16 2011 - Jul 15 2013