Rajasekhar Ramakrishnan, EngScD

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Overview

Academic Appointments

  • Senior Research Scientist in the Department of Pediatrics

Research

My research activities are in applying biostatistics and biomathematics to clinical research projects inside and outside the Department of Pediatrics. I also run a clinical research elective, taken by nearly all second year pediatrics residents, to help them finalize their resident research project proposals from the viewpoint of power analysis, and also to teach them statistical tools to help them be self-sufficient. I also teach in a Master of Science program in the Institute of Human Nutrition at the medical center.

I am co-investigator on all of the following NIH/HRSA-funded projects:

2016-2021 UL1 “Clinical and Translational Science Award” (PI: MP Reilly)

2017-2023 R35 “Phenotyping Genetic Disorders of Hepatic Lipid and Lipoprotein Metabolism in Cells, Mice, and Men” (PI:  HN Ginsberg)

2014-2018 R01 “PRISM: Personalized Reminders for Immunization using Short Messaging systems” (PI:  M Stockwell)

2015-2018 R01 “SINC: Synchronized Immunization Notifications” (PI:  M Stockwell)

2015-2020 R01 “Omega-3 Fatty Acids Acute Neuroprotection via Mitochondria” (PI: RJ Deckelbaum)

2015-2020 R01 “Postprandial Vitamin A” (PI: WS Blaner)

Grants

PHENOTYPING GENETIC DISORDERS OF HEPATIC LIPID AND LIPOPROTEIN METABOLISM IN CELLS, MICE, AND MEN (Federal Gov)

Jan 1 2017 - Dec 31 2023

CLINICAL AND TRANSLATIONAL SCIENCE AWARD (Federal Gov)

Jul 1 2016 - May 31 2021

SINC: SYNCHRONIZED IMMUNIZATION NOTIFICATIONS (Federal Gov)

Jul 1 2015 - Jun 30 2019

PRISM: PERSONALIZED REMINDERS FOR IMMUNIZATION USING SHORT MESSAGING SYSTEMS (Federal Gov)

Jul 1 2014 - Jun 30 2019

CHARACTERIZATION AND EFFECTS OF AN MCT-FISH OIL INTRAVENOUS LIPID EMULSION (Private)

Jun 1 2016 - May 31 2018

MECHANISMS OF ATHEROGENESIS IN INSULIN RESISTANCE (Federal Gov)

Feb 1 2013 - Jan 31 2018

COLUMBIA UNIVERSITY CISA ( WHEEZING STUDY) (Federal Gov)

Sep 27 2012 - Sep 26 2017

COLUMBIA UNIVERSITY CISA CENTER (Federal Gov)

Sep 27 2012 - Sep 26 2017

CLINICAL AND TRANSLATIONAL SCIENCE AWARD (UL1) (Federal Gov)

Sep 30 2006 - Jun 30 2016

CHILDHOOD FOOD INSECURITY IN THE UNDERSERVED (Federal Gov)

Mar 1 2015 - Feb 29 2016

ENDOTHELIAL OXIDATIVE STRESS AND INFLAMMATION:MECHANISMS AND HUMAN STUDIES (Federal Gov)

Feb 1 2010 - Jan 31 2016

THE METABOLIC IMPACT OF CONGENITAL HETEROZYGOUS APOC-III DEFICIENCE IN HUMANS (Federal Gov)

Jan 14 2011 - Dec 31 2015

EMSC NETWORK DEVELOPMENT DEMONSTRATION PROJECT (NDDP) (Federal Gov)

Sep 30 2001 - Aug 31 2015

ALCOHOL CONSUMPTION AND BROWN ADIPOSE TISSUE (Federal Gov)

Dec 1 2012 - Nov 30 2014

DEVISE: DATA EXCHANGE OF VACCINE INFORMATION BETWEEN AN IIS AND EHR (Federal Gov)

Sep 1 2013 - Aug 31 2014

TEXTFLUENZA: USING TECHNOLOGY TO PROMOTE FLU VACCINATION IN UNDERSERVED MATERNAL AND CHILD POPULATIONS (Federal Gov)

Feb 1 2010 - Jan 31 2014

TEXT 4 HEALTH-KIDS: TEXT MESSAGE REMINDER-RECALLS FOR EARLY CHILDHOOD VACCINATION (Federal Gov)

Sep 1 2010 - Aug 31 2013

FLU ALERT: INFLUENZA VACCINE ALERTS FOR PROVIDERS IN THE ELE CTRONIC HEALTH RECORD (Federal Gov)

Sep 30 2009 - Jul 31 2013

Selected Publications

  1. Reyes-Soffer G, Ginsberg HN, Ramakrishnan R. The metabolism of lipoprotein(a): an ever-evolving story. J Lipid Res. 58:1756-64, 2017. PMID: 28720561
  2. Ginsberg HN, Ramakrishnan R. Investigations of apoCIII metabolism using stable isotopes: what information can you acquire and how can you interpret your results? J Lipid Res. 52:1071-2, 2011. PMC3090228
  3. Ramakrishnan R, Ramakrishnan JD. A state space transformation can yield identifiable models for tracer kinetic studies with enrichment data. Bulletin of Mathematical Biology. 72:2019-46, 2010. PMC3275642
  4. Ramakrishnan R, Ramakrishnan JD. Utilizing Mass Measurements in Tracer Studies – A Systematic Approach to Efficient Modeling. Metabolism.57:1078-87, 2008. PMC2601710
  5. Rubin J, Kim HJ, Pearson TA, Holleran S, Berglund L, Ramakrishnan R. The apolipoprotein(a) gene: Linkage disequilibria at three loci differs in African Americans and Caucasians. Atherosclerosis.201:138-47, 2008. PMC2784197
  6. Ginsberg HN, Ramakrishnan R. Kinetic studies of the metabolism of rapidly exchangeable apolipoproteins may leave investigators and readers with exchangeable results. Arterioscler Thromb Vasc Biol. 28:1685-6, 2008. PMC3275632
  7. Ramakrishnan R. Alternative equations for whole-body protein synthesis and for fractional synthetic rates of proteins. Metabolism. 56:1550-60, 2007. PMC2435311
  8. Ramakrishnan R. Studying apolipoprotein turnover with stable isotope tracers - correct analysis is by modeling enrichments. J Lipid Res.47:2738-53, 2006. PMC3276318
  9. Sloan RP, Ramakrishnan R. Science, medicine, and intercessory prayer. Perspect Biol Med. 49:504-14, 2006. PMID: PMC3275584
  10. Sloan RP, Ramakrishnan R. The MANTRA II study. Lancet 366:1769-70, 2005. PMID: 16298208
  11. Berglund L, Ramakrishnan R. Lipoprotein(a): an elusive cardiovascular risk factor.  Arterioscler Thromb Vasc Biol. 24:2219-26, 2004. PMID: 15345512
  12. Dell RB, Holleran S, Ramakrishnan R. Sample size determination. ILAR J. 43:207-13, 2002. PMID: 12391396
  13. Kashyap S, Sahni R, Ramakrishnan R. Following up randomized feeding studies - a way to test the fetal programming hypothesis. Pediatr Res. 50(2 Pt 2):13A, 2001.(Presented at the First World Congress on Fetal Origins of Adult Diseases, Bombay, Feb 2001)
  14. Berglund L, Witztum JL, GaleanoNF, KhouwAS, Ginsberg HN, Ramakrishnan R. Three-fold effect of lovastatin treatment on low density lipoprotein metabolism in subjects with hyperlipidemia: increase in receptor activity, decrease in apoB production, and decrease in particle affinity for the receptor. Results from a novel triple-tracer approach. J Lipid Res. 39:913-24, 1998. PMC3988111
  15. Ginsberg HN, Karmally W, Siddiqui M, Holleran S, Tall AR, Rumsey SC, Deckelbaum RJ, Blaner WS, Ramakrishnan R. A dose-response study of the effects of dietary cholesterol on fasting and postprandial lipid and lipoprotein metabolism in healthy young men. ArteriosclerThromb. 14:576-86, 1994. PMID: 08148356
  16. Schulze K, Kashyap S, Ramakrishnan R. Cardiorespiratory costs of growth in low birth weight infants. J Dev Physiol. 19:85-90, 1993. PMID: 08409279
  17. Varma DR, Ramakrishnan R. Effects of protein-calorie malnutrition on transplacental kinetics of aminoisobutyric acid in rats. Placenta.  12:277-84, 1991. PMID: 01754576
  18. Ramakrishnan R, Arad Y, Wong S, Ginsberg HN. Nonuniform radiolabeling of VLDL apolipoprotein B: implications for the analysis of studies of the kinetics of the metabolism of lipoproteins containing apolipoprotein B. J Lipid Res. 31:1031-42, 1990. PMC3275143
  19. Ramakrishnan R, Leonard EF, Dell RB. A proof of the occupancy principle and the mean transit time theorem for compartmental models. Math Biosci. 68:121-136, 1984. doi: 10.1016/0025-5564(84)90076-2
  20. Goodman DS, Smith FR, Seplowitz AH, Ramakrishnan R, Dell RB. Prediction of the parameters of whole body cholesterol metabolism in humans. J Lipid Res.  21:699-713, 1980. PMID: 07419983