Rebecca Anne Haeusler, PhD

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Overview

Academic Appointments

  • Assistant Professor of Pathology and Cell Biology

Credentials & Experience

Education & Training

  • BS, Biology, Massachusetts Institute of Technology
  • PhD, Biological Chemistry, University of Michigan

Research

The goals of our research are to understand the development of proatherogenic metabolic abnormalities in insulin resistant individuals, and to identify new therapeutic targets for improving these abnormalities. Two current areas of focus are dysregulation of (i) lipoprotein and (ii) bile acid metabolism. Lipoproteins carry out atherogenic and atheroprotective actions, and may link insulin resistance with cardiovascular disease. Bile acids are involved in maintaining cholesterol, glucose, and triglyceride homeostasis, and are dysregulated during insulin resistance and diabetes. Through these two research areas, we aim to determine mechanisms of metabolic abnormalities and atherogenesis in the natural history of type 2 diabetes, and to identify potential therapeutic targets. 

Welcome to Haeusler Lab.

Research Interests

  • Understand the development of pro-atherogenic metabolic abnormalities in the natural history of diabetes and the metabolic syndrome

Grants

HEPATIC INSULIN ACTION AND ENDOTHELIAL FUNCTION (Private)

Jan 1 2017 - Dec 31 2019

INSULIN ACTION, REVERSE CHOLESTEROL TRANSPORT, AND HDL FUNCTION (Federal Gov)

Nov 21 2014 - Oct 31 2019

INSULIN REGULATION OF REVERSE CHOLESTEROL TRANSPORT (Federal Gov)

Jun 1 2016 - May 31 2019

BILE ACIDS AND INSULIN SENSITIVITY (Federal Gov)

Sep 15 2017 - Aug 31 2018

ROLE OF FOXO1 IN LIPID METABOLISM (Federal Gov)

Jun 1 2012 - Mar 31 2018

DIABETES AND ENDOCRINOLOGY RESEARCH CENTER (Federal Gov)

Mar 15 2013 - Jan 31 2018

2017 LIPID SYMPOSIUM (Private)

Mar 24 2017 - Mar 25 2017

MERCK-COLUMBIA (ACCILI) INSULIN SENSITZER AND BETA CELL DEDIFFERENTIATION COLLABORATION (Private)

Dec 14 2015 - Dec 13 2016

BREHM COALITION AWARD (Private)

Dec 1 2008 - Nov 30 2013

ROLE OF HEPATIC FOXO1 IN ATHEROSCLEROSIS (Federal Gov)

Sep 13 2010 - May 15 2011

HORMONES: BIOCHEMISTRY & MOLECULAR BIOPHYSICS (Federal Gov)

Sep 15 1978 - Jun 30 2010

Selected Publications

Bertaggia E, Jensen K, Castro-Perez J, Xu Y, Di Paolo G, Chan RB, Wang L, Haeusler RA. (2017) Cyp8b1 ablation prevents western diet-induced weight gain and hepatic steatosis due to impaired fat absorption. Am J Physiol Endocrinol Metab 313: E121-E133

Langlet, Haeusler RA, Linden D, Ericson E, Norris T, Johansson A, Cook JR, Aizawa K, Sang L, Buettner C, Accili D. (2017) Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling. Cell doi: 10.1016/j.cell.2017.09.045

Haeusler RA, McGraw T, and Accili D. (2017) Biochemical and cellular properties of insulin receptor signaling. Nat Rev Mol Cell Biol. 10.1038/nrm.2017.89

Haeusler RA, Camastra S, Nannipieri M, Astiarraga G, Castro-Perez J, Xie D, Wang L, Chakravarthy M, Ferrannini E. (2016) Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity. J Clin Endocrinol Metab 101:1935 

Ferrannini E, Camastra S, Astiarraga G, Nannipieri M, Castro-Perez J, Xie D, Wang L, Chakravarthy M, Haeusler RA. (2015) Increased Bile Acid Synthesis and Deconjugation after Biliopancreatic Diversion. Diabetes doi:10.2337/db15-0214

Haeusler RA, Camastra S, Astiarraga B, Nannipieri M, Anselmino N, and Ferranini E. (2014) Decreased Expression of Hepatic Glucokinase in Type 2 Diabetes. Molecular Metab. 4: 222

Haeusler RA, Hartil K, Vaitheesvaran B, Arrieta-Cruz I, Knight CM, Cook JR, Kammoun HL, Febbraio MA, Gutierrez-Juarez R, Kurland IJ, and Accili D. (2014) Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors. Nature Commun. 5: 5190

Haeusler RA, Astiarraga B, Camastra S, Accili D, and Ferrannini E. (2013) Human Insulin Resistance is Associated with Increased Plasma Levels of 12-Hydroxylated Bile Acids. Diabetes. 62: 4184

Haeusler RA, Pratt-Hyatt M, Welch CL, Klaassen CD, and Accili D. (2012) Impaired Generation of 12-Hydroxylated Bile Acids Links Hepatic Insulin Signaling with Dyslipidemia. Cell Metab. 15: 65-74