Rudolph L. Leibel, MD

Expertise in: 
Clinical Molecular Genetics and Genomics
Board Certifications: 
Pediatrics
Profile Headshot

Overview

Areas of Expertise / Conditions Treated

Clinical Molecular Genetics and Genomics, Obesity

Academic Appointments

  • Professor of Pediatrics
  • Professor of Medicine

Administrative Titles

  • Co-Director, Naomi Berrie Diabetes Center
  • Chief, Division of Pediatric Molecular Genetics

Dr. Leibel's research focuses on the genetics of obesity and noninsulin-dependent diabetes. His laboratory has mapped, cloned, and identified mutations in the obese and fatty genes in rats, mice, and, more recently, in humans. The obese gene encodes leptin, an adipose derived hormone responsible for regulating body weight, whereas the fatty gene encodes the leptin receptor. Currently, his research group is defining the physiological bases by which this and related signaling networks regulate body size and composition. For example, changes in leptin production following reduction in body fat might play a role in the metabolic changes that accompany weight loss in humans. Dr. Leibel's laboratory is also working to isolate additional rodent genes that influence body weight and the susceptibility to noninsulin dependent diabetes mellitus in the context of obesity. Laboratory members have extended their genetic studies to search for similar obesity and diabetes related genes in human families.

Hospital Affiliations

  • NewYork-Presbyterian/Morgan Stanley Children's Hospital
  • NewYork-Presbyterian/Columbia

Gender

  • Male

Location(s)

CUMC/Russ Berrie Medical Science Pavilion
1150 St. Nicholas Avenue
New York, NY 10032
Primary

Credentials & Experience

Education & Training

  • Albert Einstein College of Medicine - Yeshiva University
  • Internship: Massachusetts General Hospital
  • Residency: Massachusetts General Hospital
  • Residency: Children's Hospital of Boston
  • Fellowship: Massachusetts General Hospital

Board Certifications

  • Pediatrics

Research

Research Interests

  • Genetics of obesity and noninsulin-dependent diabetes

Grants

COLUMBIA DIABETES RESEARCH CENTER (Federal Gov)

Jul 6 2018 - Jan 31 2023

THE MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY (Federal Gov)

Sep 24 2016 - Aug 31 2021

SHORT TERM TRAINING GRANT (Federal Gov)

May 1 2016 - Apr 30 2021

NEW YORK OBESITY RESEARCH CENTER (Federal Gov)

Dec 1 1996 - Mar 31 2021

FORKHEAD BIOTHERAPEUTICS SRA (Private)

Dec 15 2017 - Jun 14 2020

FUNCTIONAL IMAGING AND EATING BEHAVIOR AMONG FTO GENOTYPES IN PRE-OBESES CHILDREN (Federal Gov)

Sep 18 2013 - Aug 31 2019

CENTER FOR IDENTIFICATION AND STUDY OF INDIVIDUALS WITH ATYPICAL DIABETES MELLLITUS (Federal Gov)

Sep 10 2018 - May 31 2019

WALLKILL (Private)

Jan 1 2018 - Dec 31 2018

MOLECULAR ANALYSES OF THE CAUSES OF DIABETES AND ITS COMPLICATIONS (Private)

Jan 1 2017 - Dec 31 2017

HELMSLEY TRUST DIABETES CELL REPOSITORY (Private)

Jan 1 2015 - Dec 31 2017

CLINICAL INVESTIGATION OF EFFICACY OF TAUROURODEOXYCHOLIC ACID (TUDCA) TO ENHANCE PANCREATIC BETA CELL SURVIVAL IN TYPE 1 DIABETES BY REDUCING ER STRESS (Private)

Oct 1 2014 - Sep 30 2017

INVESTIGATING THE ROLE OF LLDR2 IN HEPATIC STEATGOSIS AND ENDOPLASMIC RETICULUM STRESS (Private)

Sep 1 2015 - Aug 31 2017

REDUCED PROHORMONE PROCESSIN(PROHORMONE CONVERTASE 1 HYPOACTIVITY) AS A MECHANISM FOR PRADER-WILLI SYNDROME. PRE-CLINICAL ANALYSES. (Private)

Jul 15 2016 - Jul 14 2017

STUDY OF CODING VARIANTS IN HUMAN OBESITY AND THEIR FUNCTIONAL CHARACTERIZATION USING HUMAN IPSC-DERIVED CELLULAR MODELS (Federal Gov)

Sep 17 2016 - Jun 30 2017

A TWIN STUDY OF OBESITY PATHOGENESIS USING FM (Federal Gov)

Sep 1 2015 - Aug 31 2016

DIABETES STEM CELLS (Private)

Sep 1 2010 - Aug 31 2016

PEDIATRIC SCIENTIST DEVELOPMENT PROGRAM (PSDP) K12 (Federal Gov)

Jul 1 2015 - Jun 30 2016

COLLABORATIVE RESEARCH PROGRAM RELATING TO THE STUDY OF GENETIC DISEASES THROUGH WHOLE EXOME/GENOME SEQUENDING (Private)

Jul 1 2014 - Jun 30 2016

TO FUNCTIONALLY EVALUATE POSSIBLE DISEASE-CAUSING VARIANTS IDENTIFIED IN WES/WGS TO DETERMINE PATHOGENICITY OF RARE VARIANTS AND DISEASE MECHANISM. (Private)

Jul 1 2014 - Jun 30 2016

THE ROLE OF ENDOPLASMIC RETICULUM STRESS IN DIABETIC BETA CELL FAILURE (NY State Gov)

Jun 1 2014 - May 31 2016

MOLECULAR ANALYSES OF THE CAUSES OF DIABETES AND ITS COMPLICATIONS (Private)

Jan 1 2015 - Dec 31 2015

MENTOR-BASED POSTDOCTORAL FELLOWSHIP AWARD (Private)

Jul 1 2011 - Jun 30 2015

NYORC MOLECULAR GENETICS/MOLECULAR BIOLOGY CORE (Federal Gov)

Jun 10 2011 - Dec 31 2014

THE ROLE OF SNORD116@ IN PRADER-WILLI SYNDROME (Private)

Sep 1 2013 - Aug 31 2014

METABOLIC ADAPTATION AND CHANGES IN CENTRAL NERVOUS SYSTEM CIRCUITRY IN WEIGHT-PERTURBED C57BL/6J MICE (Private)

Jun 16 2008 - Nov 30 2013

BODY COMPOSITION STUDIES AND EATING BEHAVIOR (Private)

Aug 22 2013 - Nov 21 2013

LEPTIN IN HUMAN ENERGY AND NEUROENDOCINE HOMEOSTASIS (Federal Gov)

Jul 1 2003 - Sep 30 2013

USE OF STEM CELL-DERIVED NEURONS TO IDENTIFY THE MOLECULAR BASIS OF THE PRADER-WILLI SYNDROME (Private)

Jun 1 2012 - Aug 31 2013

USING STEM CELLS TO INVESTIGATE HUMAN OBESITY MUTATIONS AND SUSCEPTIBILITY ALLELES (NY State Gov)

Sep 1 2010 - Aug 31 2013

UNDERSTANDING THE MOLECULAR PATHOGENESIS OF BETA CELL FAILURE IN DIABETES (Private)

Dec 1 2012 - May 31 2013

CLONING OF A TYPE 2 DIABETES MODIFIER IN OBESE MICE (Federal Gov)

Sep 30 2003 - Apr 30 2013

NYORC MOLECULAR GENETICS/MOLECULAR BIOLOGY CORE (Federal Gov)

Jun 10 2011 - Mar 31 2013

CELL BANK FROM DIABETES PATIENTS (Private)

Aug 1 2009 - Jan 31 2013

GENERATION OF ES CELLS BY SOMATIC CELL NUCLEAR TRANSFER (SCNT) AND COMPARISON OF THEIR FUNCTIONAL ASPECTS TO STEM CELLS CREATED BY IPS (Private)

Aug 1 2009 - Jan 31 2013

UNDERSTANDING INTRINSIC BETA CELLS DEFECTS IN MONOGENIC FORMS OF DIABETES- A POSITIVE CONTROL FOR CELL-AUTONOMOUS BETA CELL DEFECTS (Private)

Aug 1 2009 - Jan 31 2013

FORMATION OF ENDOCRINE PANCREAS PROGENITORS (Federal Gov)

Jul 1 2010 - Jun 30 2012

A TWIN STUDY OF OBESITY PATHOGENESIS USING FMRI (Federal Gov)

Jul 19 2010 - Jun 30 2011

MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY (Private)

Jul 1 2007 - Jun 30 2011

NYORC MOLECULAR GENETICS/MOLECULAR BIOLOGY CORE (Federal Gov)

Apr 1 2010 - Mar 31 2011

NEW YORK OBESITY RESEARCH CENTER (Federal Gov)

Dec 1 1999 - Mar 31 2011

NYORC MOLECULAR GENETICS/MOLECULAR BIOLOGY CORE (Federal Gov)

Dec 1 1999 - Mar 31 2011

NEW YORK OBESITY RESEARCH CENTER (Federal Gov)

Dec 1 1999 - Mar 31 2011