Cathy Lee Mendelsohn, PhD

Profile Headshot

Overview

Academic Appointments

  • Professor of Urological Sciences (in Urology) and Pathology & Cell Biology and Genetics & Development (in the Institute of Human Nutrition)

Administrative Titles

  • PI, George M. O'Brien Urology Research Center

Dr. Mendelsohn obtained a BS in Microbiology from the University of Massachusetts at Amherst. She obtained a PhD in Microbiology at Columbia University Medical Center, working in Dr. Vincent Racaniello's lab where she cloned the human Poliovirus receptor. Her postdoctoral studies in Pierre Chambon's lab, at the Université Louis Pasteur, Strasbourg France were focused on Retinoic acid receptors and their role in development, studies which were continued in the lab of Jane Dodd at Columbia University looking at  the role of retinoids in kidney development. 

Languages

  • French

Credentials & Experience

Education & Training

  • PhD, 1989 Microbiology, Columbia University Graduate School of Arts and Sciences, NY

Research

Research Interests

  • Identification of progenitors important for formation and regeneration of the urothelium
  • Stem cell populations that give rise to bladder cancers
  • Genetics of lower urinary tract malformations as part of the Columbia University O'Brien Research Center (http://cumcobriencenter.com/)
  • Generating a molecular and cellular atlas of the mouse and human lower urinary tract (https://beta.gudmap.org/tutorials/urogenital-dev/)
  • Role of Pparg in urothelial development, regeneration and bladder cancer

Grants

U54 DK104309, (MENDELSOHN)  09/24/2014-07/31/2019   
“The Genetic Origins and Complications of Urinary Tract Abnormalities” The George M. O'Brien Center Urology Center. The overall focus of this award is to identify mutations in humans that cause urological birth defects and to provide outreach to the community with the goal of attracting new investigators to the field. Role: Principal Investigator 

R01 DK095044-03 (MENDELSOHN)  07/01/2013-06/30/2022   
“Retinoic acid signaling controls urothelial development and regeneration”. 
This project is focused on elucidating the role of retinoid-dependent transcription in urothelial progenitor cells. Role: Principal Investigator 

TJ Martell foundation    
"Lineage studies of bladder cancer"  
This project is focused on analyzing the cancer forming potential of urothelial cells using mouse models of bladder carcinogenesis. 
Role: Co-Investigator 

U01 DK094530-05 (MENDELSOHN)  09/30/2011-08/31/2021 
“Generating molecular markers that selectively label urothelial sub-populations.” 
This project is focused on producing an anatomical atlas of the mouse and human urinary tract. Role: Principal Investigator 

RETINOIC ACID SIGNALING CONTROLS UROTHELIAL DEVELOPMENT AND REGENERATION. (Federal Gov)

Jul 1 2017 - Jun 30 2022

GENERATING AN ATLAS OF THE DEVELOPING HUMAN URINARY OUTFLOW TRACT. (Federal Gov)

Sep 15 2016 - May 31 2021

THE GENETIC ORIGINS AND COMPLICATIONS OF URINARY TRACT ABNORMALITIES (Federal Gov)

Sep 24 2014 - Jul 31 2019

GENERATING MOLECULAR MARKERS THAT SELECTIVELY LABEL UROTHELIAL SUB-POPULATIONS. (Federal Gov)

Sep 1 2011 - Aug 31 2017

THE T.J. MARTELL FOUNDATION FOR LEUKEMIA, CANCER AND AIDS RESEARCH (Private)

Jan 1 2015 - Dec 31 2015

SUPPLEMENT TO URINARY BIOMARKERS OF LOWER URINARY TRACT SYMPTONS (LUTS) IN MEN (Federal Gov)

Jul 1 2014 - Aug 31 2015

A PROSTATE CANCER PROGRAM (Private)

Jan 1 1999 - Dec 31 2014

REGENERTION, REPAIR AND REMODELING OF THE LOWER URINARY TRACT (Federal Gov)

Sep 9 2013 - Jul 31 2014

MOLECULAR EVENTS IN URINARY TRACT FORMATION (Federal Gov)

Apr 30 2002 - Aug 31 2013

VITAMIN A DEPENDENT EVENTS IN URINARY TRACT FORMATION (Federal Gov)

Sep 15 2009 - Aug 31 2011

MURINE ATLAS OF A GENITOURINARY SMOOTH MUSCLE (Federal Gov)

Apr 1 2008 - Mar 31 2011

MURINE ATLAS OF A GENITOURINARY SMOOTH MUSCLE DEVELOPMENT (Federal Gov)

Apr 1 2008 - Mar 31 2011

APOPTOSIS REQUIRED FOR URETER TRANSPORTATION (Private)

Jan 1 2006 - Dec 31 2010

Selected Publications

An illustrated anatomical ontology of the developing mouse lower urogenital tract.

PubMed Id: 25968320. Authors: Georgas KM Armstrong J Keast JR Larkins CE McHugh KM Southard-Smith EM Cohn MJ Batourina E Dan H Schneider K Buehler DP Wiese CB Brennan J Davies JA Harding SD Baldock RA Little MH Vezina CM Mendelsohn C

Tumorigenicity of RTK/RAS in urothelium.

PubMed Id: 26501074. Authors: Wu XR Mendelsohn C DeGraff DJ

Bladder cancers arise from distinct urothelial sub-populations.

PubMed Id: 25218638. Authors: Van Batavia J Yamany T Molotkov A Dan H Mansukhani M Batourina E Schneider K Oyon D Dunlop M Wu XR Cordon-Cardo C Mendelsohn C

Formation and regeneration of the urothelium.

PubMed Id: 24752063. Authors: Yamany T Van Batavia J Mendelsohn C

Retinoid signaling in progenitors controls specification and regeneration of the urothelium.

PubMed Id: 23993789. Authors: Gandhi D Molotkov A Batourina E Schneider K Dan H Reiley M Laufer E Metzger D Liang F Liao Y Sun TT Aronow B Rosen R Mauney J Adam R Rosselot C Van Batavia J McMahon A McMahon J Guo JJ Mendelsohn C